This course provides the 2 hours of Nevada State Board approved safe opioid prescribing continuing education (CE) required for all Nevada Advanced Practice Registered Nurses (APRNs) for licensing and relicensing. It equips participants with the necessary knowledge and clinical strategies for safe and compliant opioid prescribing, fulfilling Nevada’s training mandates for opioid and substance use disorder. Through four modules, learners will delve into Nevada’s opioid crisis, the neurobiology of addiction, and safe prescribing techniques that adhere to CDC guidelines and state law. The curriculum emphasizes harm reduction, SBIRT protocols, risk identification, and the Nevada Prescription Monitoring Program (PMP). Moreover, it focuses on informed consent, patient education, non-opioid alternatives, and strategies to avoid common pitfalls in prescribing.